Environmental Pathology

Legionella: from environmental habitats to disease pathology, detection and control.

Studies on Legionella show a continuum from environment to human disease. Legionellosis is caused by Legionella species acquired from environmental sources, principally water sources such as cooling towers, where Legionella grows intracellularly in protozoa within biofilms. Aquatic biofilms, which are widespread not only in nature, but also in medical and dental devices, are ecological niches i...

Anatomic Pathology / PATHOLOGY OF THE SYNOVIUM Pathology of the Synovium

Synovium is specialized mesenchymal tissue that is essential for the appropriate function of the locomotor apparatus. It is the site for a series of pathologic processes that are characteristic, and in some cases specific, to this distinctive tissue. In this article, the normal microscopic anatomy of synovium is briefly reviewed. Synovial proliferative disorders, including pigmented villonodula...

Female hippocampus vulnerability to environmental stress, a precipitating factor in Tau aggregation pathology.

Tau-mediated neurodegeneration is a central event in Alzheimer's disease (AD) and other tauopathies. Consistent with suggestions that lifetime stress may be a clinically-relevant precipitant of AD pathology, we previously showed that stress triggers Tau hyperphosphorylation and accumulation; however, little is known about the etiopathogenic interaction of chronic stress with other AD risk facto...

Pathology

A system of learning pathology based on new teaching methods is described and compared with traditional teaching. The Integrated Pathology Audiovisual Learning System (IPALS) is the product of an international team of pathologists and consists of three tiers. Tier I deals with general pathology, Tier II with the pathology of organ systems, and Tier III with diseases in individual organs. Each u...

Pathology